The effect of dinitrosyl iron complexes with glutathione and S-nitrosoglutathione on the development of experimental endometriosis in rats: A comparative studies

It has been established that intraperitoneal bolus administration of S-nitrosoglutathione (GS-NO) (12.5μmoles/kg; 10 injections in 10 days), beginning with day 4 after transplantation of two 2-mm autologous fragments of endometrial tissue onto the inner surface of the abdominal wall of rats with sur...

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Published inEuropean journal of pharmacology Vol. 741; pp. 37 - 44
Main Authors Burgova, Evgeniya N., Tkachev, Nikolai А., Paklina, Oksana V., Mikoyan, Vasak D., Adamyan, Leila V., Vanin, Anatoly F.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.10.2014
Subjects
Animals
Dinitrosyl iron complex
Drug Combinations
Endometriosis
Endometriosis - pathology
Endometriosis - prevention & control
Female
Glutathione - administration & dosage
Iron - administration & dosage
Nitrogen Oxides - administration & dosage
Rats
Rats, Wistar
S-nitrosoglutathione
S-Nitrosoglutathione - administration & dosage
Treatment Outcome
Dinitrosyl iron complex
HFS
MNIC-DETC
EPR
Endometriosis
B- or M-DNIC
GS-NO
SNAP
S-nitrosoglutathione
EMT
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Summary:It has been established that intraperitoneal bolus administration of S-nitrosoglutathione (GS-NO) (12.5μmoles/kg; 10 injections in 10 days), beginning with day 4 after transplantation of two 2-mm autologous fragments of endometrial tissue onto the inner surface of the abdominal wall of rats with surgically induced (experimenta) endometriosis failed to prevent further growth of endometrioid (EMT) and additive tumors, while treatment of animals with dinitrosyl iron complexes (DNIC) with glutathione (12.5μmoles/kg, 10 injections in 10 days) suppressed tumor growth virtually completely. The histological analysis of EMT samples of GS-NO-treated rats revealed pathological changes characteristic of control (non-treated with GS-NO or DNIC) rats with experimental endometriosis. EPR studies established the presence of the active form of ribonucleotide reductase, a specific marker for rapidly proliferating tumors, in EMT samples of both control and GS-NO-treated animals. Noteworthy, in small-size EMT and adjacent tissues of DNIC-treated rats the active form of ribonucleotide reductase and pathological changes were not found.
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ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2014.07.017