Subcutaneous amyloid-tumor of beta-2-microglobulin origin in a long-term hemodialysis patient

beta 2-Microglobulin (beta 2M)-derived amyloidosis has become a major concern in long-term hemodialysis patients. Clinical symptomatology is largely restricted to the articular and periarticular sites and in rare cases systemic manifestations have been described. We present a long-term hemodialysis...

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Published inNephron (2015) Vol. 53; no. 1; p. 73
Main Authors Floege, J, Brandis, A, Nonnast-Daniel, B, Westhoff-Bleck, M, Tiedow, G, Linke, R P, Koch, K M
Format Journal Article
LanguageEnglish
Published Switzerland 1989
Subjects
Amyloidosis - etiology
Amyloidosis - pathology
beta 2-Microglobulin - physiology
Buttocks
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
Male
Middle Aged
Renal Dialysis - adverse effects
Skin Neoplasms - etiology
Skin Neoplasms - pathology
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Summary:beta 2-Microglobulin (beta 2M)-derived amyloidosis has become a major concern in long-term hemodialysis patients. Clinical symptomatology is largely restricted to the articular and periarticular sites and in rare cases systemic manifestations have been described. We present a long-term hemodialysis patient, who after 16 years of hemodialysis with regenerated cellulosic membranes not only had a bilateral carpal tunnel syndrome, cystic bone translucencies and humeroscapular periarthritis but also developed two subcutaneous tumors in both gluteal regions, causing discomfort when sitting. Histology, immunohistology and electron microscopy of the tumor from the right side showed that it consisted of beta 2M-derived amyloid with concurrent scattered amyloid infiltration of the overlying skin. This report therefore adds a new clinical manifestation to the symptomatology of this type of amyloid.
ISSN:1660-8151
2235-3186
DOI:10.1159/000185706