Parecoxib sodium in the treatment of postoperative pain after Lichtenstein tension-free mesh inguinal hernia repair

Purpose This prospective, randomized, double-blind study compared the analgesic efficacy and safety of parecoxib sodium versus lornoxicam and diclofenac, after Lichtenstein tension-free mesh inguinal hernia repair. Methods Patients were randomly assigned to receive parecoxib 80 mg daily i.v. (Group...

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Published inHernia : the journal of hernias and abdominal wall surgery Vol. 15; no. 1; pp. 59 - 64
Main Authors Kyriakidis, A. V., Perysinakis, I., Alexandris, I., Athanasiou, K., Papadopoulos, Ch, Mpesikos, I.
Format Journal Article
LanguageEnglish
Published Paris Springer-Verlag 01.02.2011
Springer Nature B.V
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Summary:Purpose This prospective, randomized, double-blind study compared the analgesic efficacy and safety of parecoxib sodium versus lornoxicam and diclofenac, after Lichtenstein tension-free mesh inguinal hernia repair. Methods Patients were randomly assigned to receive parecoxib 80 mg daily i.v. (Group A), lornoxicam 16 mg daily i.v. (Group B) or diclofenac 150 mg daily i.m. (Group C). Rescue analgesia in all groups consisted of pethidine 25 mg i.m. Pain was measured with an analogue scale (pain intensity score). Results Patients treated with parecoxib 80 mg reported significantly lower summed pain intensity scores compared with lornoxicam and diclofenac-treated patients. Duration of analgesia was also significantly longer with parecoxib than with lornoxicam and diclofenac. Adverse events were significantly less common in the parecoxib and lornoxicam group, compared with diclofenac group. Conclusions Multiple-day administration of parecoxib 40 mg twice daily is more effective than equivalent doses of lornoxicam and diclofenac, and generally better tolerated than diclofenac after Lichtenstein tension-free mesh inguinal hernia repair.
ISSN:1265-4906
1248-9204
DOI:10.1007/s10029-010-0737-1