Francisella tularensis intracellular survival: to eat or to die

Francisella tularensis is a highly infectious facultative intracellular bacterium causing the zoonotic disease tularemia. Numerous attributes required for F. tularensis intracellular multiplication have been identified recently. However, the mechanisms by which the majority of them interfere with th...

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Bibliographic Details
Published inMicrobes and infection Vol. 15; no. 14-15; pp. 989 - 997
Main Authors Barel, Monique, Charbit, Alain
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.12.2013
Subjects
Francisella tularensis
Intracellular parasitism
Nutritional immunity
Intracellular parasitism
Nutritional immunity
Francisella tularensis
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Summary:Francisella tularensis is a highly infectious facultative intracellular bacterium causing the zoonotic disease tularemia. Numerous attributes required for F. tularensis intracellular multiplication have been identified recently. However, the mechanisms by which the majority of them interfere with the infected host are still poorly understood. The following review summarizes our current knowledge on the different steps of Francisella intramacrophagic life cycle and expands on the importance of nutrient acquisition.
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ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2013.09.009