The sites of deep vascular schizogony in chloroquine-resistant Plasmodium berghei in mice

4 mice were infected with chloroquine-resistant P. berghei. 5–7 days later tail blood and crushes of the organs were stained with Giemsa. The stage of development (trophozoite or schizont) and parasitaemia were determined for each slide. The schizonts concentrated in the liver, spleen and bone marro...

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Published inTransactions of the Royal Society of Tropical Medicine and Hygiene Vol. 63; no. 2; pp. 195 - 197
Main Authors Miller, L.H., Fremount, H.N.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 1969
Royal Society of Tropical Medicine and Hygiene
Subjects
Animals
Bone Marrow - microbiology
Brain - microbiology
Chloroquine - pharmacology
Drug Resistance, Microbial
Female
Heart - microbiology
Kidney - microbiology
Liver - microbiology
Lung - microbiology
Malaria - microbiology
Mice
Plasmodium - drug effects
Plasmodium - growth & development
Plasmodium - isolation & purification
Spleen - microbiology
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Summary:4 mice were infected with chloroquine-resistant P. berghei. 5–7 days later tail blood and crushes of the organs were stained with Giemsa. The stage of development (trophozoite or schizont) and parasitaemia were determined for each slide. The schizonts concentrated in the liver, spleen and bone marrow and not in the heart, brain, lung and kidney. This organ distribution overlaps with that of P. coatneyi except for the paucity of schizonts in the heart of mice infected with chloroquine-resistant P. berghei.
Bibliography:Supported by National Institutes of Health Training Grant 5-TI-AI-55-09.
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ISSN:0035-9203
1878-3503
DOI:10.1016/0035-9203(69)90146-1