Treatment of imported cases of falciparum malaria in France with halofantrine

Halofantrine is a 9-phenanthrenemethanol which is effective against multi-drug resistant strains of Plasmodium falciparum. It has been shown to be highly effective and extremely well tolerated in the treatment of imported cases of falciparum malaria in France. A total of 1,500 mg administered in thr...

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Published inTransactions of the Royal Society of Tropical Medicine and Hygiene Vol. 80; no. 4; pp. 615 - 617
Main Authors Coulaud, J.P., Le Bras, J., Matheron, S., Moriniere, B., Saimot, A.G., Rossignol, J.F.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 1986
Royal Society of Tropical Medicine and Hygiene
Subjects
Adult
Antimalarials - therapeutic use
Female
France
Humans
Malaria - drug therapy
Malaria - immunology
Male
Middle Aged
Phenanthrenes - administration & dosage
Phenanthrenes - therapeutic use
Plasmodium falciparum
France
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Summary:Halofantrine is a 9-phenanthrenemethanol which is effective against multi-drug resistant strains of Plasmodium falciparum. It has been shown to be highly effective and extremely well tolerated in the treatment of imported cases of falciparum malaria in France. A total of 1,500 mg administered in three 500 mg doses at six-hour intervals results in a 100% cure rate in semi-immune subjects. This dosage should be repeated after 14 days to obtain the same cure rate in non-immune patients. Minor clinical side effects included epigastric pains, nausea and, in one case, a skin rash.
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0035-9203
1878-3503
DOI:10.1016/0035-9203(86)90158-6