Towards the CSNK2 phosphoproteome – With lessons from the COVID-19 pandemic to revealing the secrets of CSNK2 and its promise as a therapeutic target

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 10; p. 130441
• Main Authors: Litchfield, David W., Gyenis, Laszlo, Menyhart, Daniel, Roffey, Scott E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2023
• Subjects: COVID-19 infection; CSNK2 (formerly CK2 or casein kinase II); CSNK2 phosphoproteome; CSNK2 viral interactions; landscapes; non-specific serine/threonine protein kinase; pathophysiology; phosphoproteome; Phosphoproteomics; physiology; proteomics; SGC-CK2-1; therapeutics; CSNK2 (formerly CK2 or casein kinase II); SGC-CK2-1; Phosphoproteomics; CSNK2 phosphoproteome; CSNK2 viral interactions
• ISSN: 0304-4165; 1872-8006; 1872-8006
• DOI: 10.1016/j.bbagen.2023.130441

Dramatic advances in phosphoproteomics and the development of a selective chemical probe have presented new opportunities for revealing the cellular landscape of substrates for CSNK2 (formerly known as CK2 or casein kinase II). In addition to deciphering the role(s) of CSNK2 in physiology and pathophysiology, the CSNK2 phosphoproteome offers the promise of instructing the development of CSNK2-targeted therapy. •CSNK2 (formerly CK2 or casein kinase II) is implicated in many cellular processes.•Combining phosphoproteomics and chemical biology to reveal the CSNK2 phosphoproteome.•COVID-19 pandemic has amplified interest in role of CSNK2 in viral infection.•CSNK2 has promise as therapeutic target including viral infection.