Investigation of interactions in 4-aminosalicylic acid/polysaccharide in aqueous media

• Published in: Food research international Vol. 43; no. 8; pp. 2077 - 2080
• Main Authors: Xu, Dongying, Zhao, Mouming, Ren, Jiaoyan, Li, Guangji, Liao, Zhengfu
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.10.2010; Elsevier
• Subjects: 4-aminosalicylic acid; Aqueous solutions; Biological and medical sciences; Complexation; Differential scanning calorimetry; Fluorescence; Food industries; Foods; Fundamental and applied biological sciences. Psychology; Hydrogen bonds; Interaction; Konjac glucomannan; Spectra; X-rays; Konjac glucomannan; 4-aminosalicylic acid; Interaction; Polysaccharide; Glucomannan
• ISSN: 0963-9969; 1873-7145
• DOI: 10.1016/j.foodres.2010.06.011

Wide angle X-ray diffraction patterns, differential scanning calorimetry, UV–vis spectra and steady-state fluorescence spectroscopy were used to examine the interactions of konjac glucomannan (KGM) and 4-aminosalicylic acid (4-ASA) in aqueous solutions. The results showed that there exist hydrogen bonds between 4-ASA and KGM, and the presence of KGM can cause the fluorescence quench in 4-ASA aqueous solution. The association constant of K a is 77.32 L/mol, and the number of binding sites per sugar-ring is 0.94 (R = 0.991). The value 0.94 indicates1:1 complexation of the drug of 4-ASA with sugar-ring on the chain of KGM. These results provide useful information for the practical application of these 4-ASA-polysaccharide systems in food and pharmaceutical industries.