Coexistence of anti-topoisomerase I and anticentromere antibodies in a patient with systemic sclerosis. Efficacy of treatment combining rituximab and nintedanib. A case report

In the diagnostic of systemic sclerosis (SSc), both anti-centromere (ACA) and anti-topoisomerase I (ATA) antibodies are considered mutually exclusive, though their coexistence has been also reported in some patients. Notably, nintedanib has been approved for the treatment of interstitial lung diseas...

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Published inInternational journal of immunopathology and pharmacology Vol. 36; p. 3946320221115310
Main Authors Montolio-Chiva, Lydia, Carmona-Talavera, Diego, López-Ortega, Jose M, Orenes-Vera, Ana V, Flores-Fernández, Eduardo, Alegre-Sancho, Juan J
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.07.2022
Sage Publications Ltd
Subjects
Antibodies
Case Report
Case reports
Coexistence
DNA topoisomerase
Immunomodulation
Immunotherapy
Lung diseases
Monoclonal antibodies
Patients
Phenotypes
Rituximab
Scleroderma
Seroconversion
Systemic sclerosis
anti-centromere antibodies
anti-topoisomerase I antibodies
nintedanib
systemic sclerosis
immunological seroconversion
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Summary:In the diagnostic of systemic sclerosis (SSc), both anti-centromere (ACA) and anti-topoisomerase I (ATA) antibodies are considered mutually exclusive, though their coexistence has been also reported in some patients. Notably, nintedanib has been approved for the treatment of interstitial lung disease associated to SSc. Herein, we present the clinical case of a 41-year-old woman with SSc who shows an immunological seroconversion (from ACA positivity to a coexistence of ACA and ATA antibodies) together with changes in her clinical phenotype. Besides, the patient responds positively to the treatment of her lung involvement with a combination of immunomodulators and antifibrotic agents.
Bibliography:ObjectType-Case Study-2
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Lydia Montolio-Chiva and Diego Carmona-Talavera contributed equally to this paper
ISSN:0394-6320
2058-7384
DOI:10.1177/03946320221115310