The Role of Primary Cilia in Thyroid Cancer: From Basic Research to Clinical Applications

Primary cilia (PC) are microtubule-based organelles that are present on nearly all thyroid follicle cells and play an important role in physiological development and in maintaining the dynamic homeostasis of thyroid follicles. PC are generally lost in many thyroid cancers (TCs), and this loss has be...

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Published inFrontiers in endocrinology (Lausanne) Vol. 12; p. 685228
Main Authors Ma, Cheng-Xu, Ma, Xiao-Ni, Li, Ying-Dong, Fu, Song-Bo
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 08.06.2021
Subjects
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
cell cycle
Cilia - drug effects
Cilia - metabolism
Cilia - pathology
ciliogenesis
Endocrinology
Hedgehog Proteins - metabolism
Humans
Mitogen-Activated Protein Kinases - metabolism
Phosphatidylinositol 3-Kinases - metabolism
primary cilium
Signal Transduction
therapeutic strategy
thyroid cancer
Thyroid Gland - metabolism
Thyroid Gland - pathology
Thyroid Neoplasms - drug therapy
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
primary cilium
thyroid cancer
therapeutic strategy
cell cycle
ciliogenesis
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Summary:Primary cilia (PC) are microtubule-based organelles that are present on nearly all thyroid follicle cells and play an important role in physiological development and in maintaining the dynamic homeostasis of thyroid follicles. PC are generally lost in many thyroid cancers (TCs), and this loss has been linked to the malignant transformation of thyrocytes, which is regulated by PC-mediated signaling reciprocity between the stroma and cancer cells. Restoring PC on TC cells is a possible promising therapeutic strategy, and the therapeutic response and prognosis of TC are associated with the presence or absence of PC. This review mainly discusses the role of PC in the normal thyroid and TC as well as their potential clinical utility.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
Edited by: Carlos Suarez, University of Oviedo, Spain
This article was submitted to Cancer Endocrinology, a section of the journal Frontiers in Endocrinology
Reviewed by: Hua Chen, University of Miami, United States; Gianluca Baldanzi, Università degli Studi del Piemonte Orientale, Italy
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2021.685228