Oxidation and pH responsive nanoparticles based on ferrocene-modified chitosan oligosaccharide for 5-fluorouracil delivery

• Published in: Carbohydrate polymers Vol. 114; pp. 27 - 35
• Main Authors: Xu, Youqian, Wang, Liang, Li, Ya-Kun, Wang, Cai-Qi
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 19.12.2014; Elsevier
• Subjects: 5-Fluorouracil; Antimetabolites, Antineoplastic - chemistry; Antimetabolites, Antineoplastic - metabolism; Antineoplastic agents; Applied sciences; Biological and medical sciences; Chemotherapy; Chitosan - chemistry; Chitosan - metabolism; Chitosan oligosaccharide; Drug Carriers - chemistry; Drug Carriers - metabolism; Drug Delivery Systems - methods; Exact sciences and technology; Ferrocene; Ferrous Compounds - metabolism; Fluorouracil - chemistry; Fluorouracil - metabolism; Hydrogen-Ion Concentration; Inorganic and organomineral polymers; Medical sciences; Metallocenes; Nanoparticles - chemistry; Nanoparticles - metabolism; Oxidation-Reduction; Pharmacology. Drug treatments; Physicochemistry of polymers; Properties and characterization; Stimuli-responsive nanoparticles; Synergistic effect; X-Ray Diffraction; Sodium hypochlorite (PubChem CID: 23665760); 5-Fluorouracil (PubChem CID: 3385); Ferrocenecarboxaldehyde (PubChem CID: 114595); 5-Fluorouracil; Stimuli-responsive nanoparticles; Hydrogen peroxide (PubChem CID: 784); Chitosan oligosaccharide; Synergistic effect; Sodium tetrahydridoborate (PubChem CID: 4311764); Ferrocene; Antineoplastic agent; Nanoparticle; Organometallic polymer; Drug carrier; Oligomer; Redox polymer; Metallocene; pH; Molecular aggregation; Release; Fluorouracil; Amphiphilic polymer; Condensation reaction; Control release polymer; Experimental study; In vitro; Particle size distribution; Chemical modification; Chitosan derivatives; Ferrocene derivative polymer; Medium effect; Preparation; Oside polymer; Chitosan; Kinetics; Aqueous solution

•The nanoparticles of FcCOS have been prepared via the self-assemble method.•The nanoparticles showed sensitive to subtle pH change of surroundings.•NaClO, H2O2 and oxygen played a positive role in promoting disassembly.•The release of 5-FU showed a synergistic effect of pH and oxygen.•We reported a...