Oxidation and pH responsive nanoparticles based on ferrocene-modified chitosan oligosaccharide for 5-fluorouracil delivery

• Published in: Carbohydrate polymers Vol. 114; pp. 27 - 35
• Main Authors: Xu, Youqian, Wang, Liang, Li, Ya-Kun, Wang, Cai-Qi
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 19.12.2014; Elsevier
• Subjects: 5-Fluorouracil; Antimetabolites, Antineoplastic - chemistry; Antimetabolites, Antineoplastic - metabolism; Antineoplastic agents; Applied sciences; Biological and medical sciences; Chemotherapy; Chitosan - chemistry; Chitosan - metabolism; Chitosan oligosaccharide; Drug Carriers - chemistry; Drug Carriers - metabolism; Drug Delivery Systems - methods; Exact sciences and technology; Ferrocene; Ferrous Compounds - metabolism; Fluorouracil - chemistry; Fluorouracil - metabolism; Hydrogen-Ion Concentration; Inorganic and organomineral polymers; Medical sciences; Metallocenes; Nanoparticles - chemistry; Nanoparticles - metabolism; Oxidation-Reduction; Pharmacology. Drug treatments; Physicochemistry of polymers; Properties and characterization; Stimuli-responsive nanoparticles; Synergistic effect; X-Ray Diffraction; Sodium hypochlorite (PubChem CID: 23665760); 5-Fluorouracil (PubChem CID: 3385); Ferrocenecarboxaldehyde (PubChem CID: 114595); 5-Fluorouracil; Stimuli-responsive nanoparticles; Hydrogen peroxide (PubChem CID: 784); Chitosan oligosaccharide; Synergistic effect; Sodium tetrahydridoborate (PubChem CID: 4311764); Ferrocene; Antineoplastic agent; Nanoparticle; Organometallic polymer; Drug carrier; Oligomer; Redox polymer; Metallocene; pH; Molecular aggregation; Release; Fluorouracil; Amphiphilic polymer; Condensation reaction; Control release polymer; Experimental study; In vitro; Particle size distribution; Chemical modification; Chitosan derivatives; Ferrocene derivative polymer; Medium effect; Preparation; Oside polymer; Chitosan; Kinetics; Aqueous solution
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2014.08.003

•The nanoparticles of FcCOS have been prepared via the self-assemble method.•The nanoparticles showed sensitive to subtle pH change of surroundings.•NaClO, H2O2 and oxygen played a positive role in promoting disassembly.•The release of 5-FU showed a synergistic effect of pH and oxygen.•We reported a dual-responsive nanoparticle of FcCOS for drug delivery. Stimuli-responsive nanoparticles based on biodegradable and biocompatible saccharides are potentially superior carriers under different physical conditions. In this study, we present a detailed investigation on the oxidation and pH responses of ferrocene-modified chitosan oligosaccharide (FcCOS) nanoparticles for 5-Fluorouracil (5-FU) Delivery. The dispersion of FcCOS nanoparticles depends strongly on pH change. NaClO, H2O2 and oxygen, as oxidant models, in a weak acid solution displayed varying accelerations as the disassembly progressed. 5-FU, as a drug model, is efficiently uploaded in FcCOS nanoparticle (approximately 238nm). The in vitro release of 5-FU from FcCOS nanoparticles studies show that the accumulative release increased with the decrease of pH under bubbled N2. Interestingly, the sample under bubbled air has a higher accumulative release up to 59.64% at pH 3.8, compared with samples under bubbled N2 just 49.02%. The results suggested that FcCOS nanoparticles disassembled faster and the release of drug molecules was accelerated because of the synergistic effect of oxidative agent and low pH. Thus, FcCOS can be developed as an effective pH and oxidation dual-responsive carrier to enhance drug efficacy for cancer treatment.