Variability Analysis of HIV-1 gp120 V3 Region: IV. Distribution Functions for Intra- and Inter- Subtype Amino Acid Hamming Distances

Distribution functions for intra- and inter- HIV-1 V3-loop subtypes amino acid Hamming distances were calculated (850 V3-loop sequences from the Los Alamos HIV-1 Database (1996) were used). These functions have pronounced bell-like shape. Such shapes of the histograms for HIV-1 V3 intra- and inter-s...

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Published inJournal of biomolecular structure & dynamics Vol. 15; no. 5; pp. 877 - 885
Main Authors Shchelkanov, Michael Yu, Starikov, Nicole S., Yaroslavtsev, Ilya V., Tsvetkov, Philip O., Yudin, Alex N., Denisov, Maxim V., Slavsky, Alexander A., Vedenov, Alexander A., Karamov, Edward V.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.04.1998
Subjects
AIDS/HIV
Amino Acids
HIV Envelope Protein gp120 - chemistry
Humans
Mathematical Computing
Peptide Fragments - chemistry
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Summary:Distribution functions for intra- and inter- HIV-1 V3-loop subtypes amino acid Hamming distances were calculated (850 V3-loop sequences from the Los Alamos HIV-1 Database (1996) were used). These functions have pronounced bell-like shape. Such shapes of the histograms for HIV-1 V3 intra- and inter-subtype distriutions are discussed to confirm the applicability of different hierarchical cluster procedures (see ref. 17) for HIV-I V3 classification. Two-mode distribution for the subtype E could sertificate that this subtype includes two thinner taxons.
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ISSN:0739-1102
1538-0254
DOI:10.1080/07391102.1998.10508209