Different Mechanisms of Syndecan-1 Activation through a Fibroblast-growth-factor-inducible Response Element (FiRE) in Mucosal and Cutaneous Wounds
Syndecan-1 expression is enhanced in cutaneous and mucosal wounds. We have previously demonstrated that wounding-induced syndecan-1 expression in the skin occurs transcriptionally, through a fibroblast-growth-factor-inducible element (FiRE). Here, we show that FiRE is also activated in mucosal wound...
Saved in:
Published in | Journal of dental research Vol. 82; no. 5; pp. 382 - 387 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
SAGE Publications
01.05.2003
SAGE PUBLICATIONS, INC |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Syndecan-1 expression is enhanced in cutaneous and mucosal wounds. We have previously
demonstrated that wounding-induced syndecan-1 expression in the skin occurs
transcriptionally, through a fibroblast-growth-factor-inducible element (FiRE). Here,
we show that FiRE is also activated in mucosal wounds. However, both the expression
patterns and the activation mechanisms of FiRE are different from those in the skin.
In the mucosa in vivo, the activation starts and ends
earlier than in cutaneous wounds. FiRE is first detected at around 12 hours in
keratinocytes, and the activation declines by the third day after wounding occurs.
The activation is seen on the migrating sheet of epithelial mucosa, as in the case of
cutaneous wounding. In contrast to the situation in
vivo, organ-cultured mucosal wounds exhibit no FiRE activity, while
organ-cultured cutaneous wounds show robust activity. Activation in mucosal wounds is
enhanced, however, by the application of epidermal growth factor. This suggests that
exogenous growth factor activity is required for activation of syndecan-1 in mucosal
wounds but not in cutaneous wounds. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-0345 1544-0591 |
DOI: | 10.1177/154405910308200511 |