Molecular mechanism of miRNA mediated biosynthesis of secondary metabolites in medicinal plants

• Published in: Plant physiology and biochemistry Vol. 208; p. 108524
• Main Authors: Li, Hongwei, Guo, Ziyi, Xu, Mengwei, Zhao, Juanjuan, Xu, Delin
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.03.2024
• Subjects: bioreactors; Biosynthesis; industrialization; Medicinal plants; microRNA; miRNA; Molecular mechanism; pharmaceutical industry; plant growth; research and development; Secondary metabolism; secondary metabolites; Medicinal plants; miRNA; Biosynthesis; Secondary metabolism; Molecular mechanism
• ISSN: 0981-9428; 1873-2690; 1873-2690
• DOI: 10.1016/j.plaphy.2024.108524

Plant secondary metabolites are important raw materials for the pharmaceutical industry, and their biosynthetic processes are subject to diverse and precise regulation by miRNA. The identification of miRNA molecules in medicinal plants and exploration of their mechanisms not only contribute to a deeper understanding of the molecular genetic mechanisms of plant growth, development and resistance to stress, but also provide a theoretical basis for elucidating the pharmacological effects of authentic medicinal materials and constructing bioreactors for the synthesis of medicinal secondary metabolite components. This paper summarizes the research reports on the discovery of miRNA in medicinal plants and their regulatory mechanisms on the synthesis of secondary metabolites by searching the relevant literature in public databases. It summarizes the currently discovered miRNA and their functions in medicinal plants, and summarizes the molecular mechanisms regulating the synthesis and degradation of secondary metabolites. Furthermore, it provides a prospect for the research and development of medicinal plant miRNA. The compiled information contributes to a comprehensive understanding of the research progress on miRNA in medicinal plants and provides a reference for the industrial development of related secondary metabolite biosynthesis. [Display omitted] •miRNAs identified to regulate plant metabolite synthesis.•Paper reviews miRNA roles in medicinal plants.•Mechanisms of metabolite control discussed.•Aids miRNA research and industrial application.