Structure and Function of TET Enzymes
Mammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC). TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). TET enzymes and oxidized 5mC derivatives play important roles in variou...
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Published in | Advances in experimental medicine and biology Vol. 945; p. 275 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
01.01.2016
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Subjects | |
Online Access | Get more information |
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Summary: | Mammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC). TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). TET enzymes and oxidized 5mC derivatives play important roles in various biological and pathological processes, including regulation of DNA demethylation, gene transcription, embryonic development, and oncogenesis. In this chapter, we will discuss the discovery of TET-mediated 5mC oxidation and the structure, function, and regulation of TET enzymes. |
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ISSN: | 0065-2598 |
DOI: | 10.1007/978-3-319-43624-1_12 |