Synergistic Action of Copper Catalysts and Lewis Acids in Carbon-Carbon Bond Forming Reactions

• Published in: Chimia Vol. 72; no. 9; p. 642
• Main Authors: Das, Manas, Harutyunyan, Syuzanna
• Format: Journal Article
• Language: English; German
• Published: Switzerland Swiss Chemical Society 01.09.2018
• Subjects: Alkylation; Asymmetric catalysis; Copper; Grignard reagents; Lewis acid

Combining Lewis acids with copper catalysis and highly reactive Grignard reagents allows fine tuning of the reactivity and selectivity of both inherently unreactive and highly reactive electrophilic substrates in asymmetric C-C bond forming reactions. In this review we will discuss various examples...