Synergistic Action of Copper Catalysts and Lewis Acids in Carbon-Carbon Bond Forming Reactions

Combining Lewis acids with copper catalysis and highly reactive Grignard reagents allows fine tuning of the reactivity and selectivity of both inherently unreactive and highly reactive electrophilic substrates in asymmetric C-C bond forming reactions. In this review we will discuss various examples...

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Bibliographic Details
Published inChimia Vol. 72; no. 9; p. 642
Main Authors Das, Manas, Harutyunyan, Syuzanna
Format Journal Article
LanguageEnglish
German
Published Switzerland Swiss Chemical Society 01.09.2018
Subjects
Alkylation
Asymmetric catalysis
Copper
Grignard reagents
Lewis acid
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Summary:Combining Lewis acids with copper catalysis and highly reactive Grignard reagents allows fine tuning of the reactivity and selectivity of both inherently unreactive and highly reactive electrophilic substrates in asymmetric C-C bond forming reactions. In this review we will discuss various examples where the application of this strategy provides access to efficient catalytic processes for the synthesis of chiral molecules such as alcohols, amides and heteroarenes.
ISSN:0009-4293
2673-2424
DOI:10.2533/chimia.2018.642