Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H2S production: A paradox resolved

Appropriately responding and adapting to genotoxic, oxidative, and metabolic stress is essential for survival and is at the heart of maintaining homeostasis. In this issue of Cell Chemical Biology, Jiang et al. (2021) describe an autophagy-dependent mechanism for cytoprotective H2S generation initia...

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Bibliographic Details
Published inCell chemical biology Vol. 28; no. 12; pp. 1665 - 1668
Main Authors Hine, Christopher, Wainwright, Derek A., Lathia, Justin D.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 16.12.2021
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Summary:Appropriately responding and adapting to genotoxic, oxidative, and metabolic stress is essential for survival and is at the heart of maintaining homeostasis. In this issue of Cell Chemical Biology, Jiang et al. (2021) describe an autophagy-dependent mechanism for cytoprotective H2S generation initiated by DNA damage and other small molecule treatments. Appropriately responding and adapting to genotoxic, oxidative, and metabolic stress is essential for survival and is at the heart of maintaining homeostasis. In this issue of Cell Chemical Biology, Jiang et al. (2021) describe an autophagy-dependent mechanism for cytoprotective H2S generation initiated by DNA damage and other small molecule treatments.
ISSN:2451-9456
2451-9456
DOI:10.1016/j.chembiol.2021.11.007