Autoimmune Hemolytic Anemia with Reticulocytopenia and Erythroid Marrow

• Published in: The New England journal of medicine Vol. 306; no. 5; pp. 281 - 286
• Main Authors: Conley, C. Lockard, Lippman, Scott M, Ness, Paul M, Petz, Lawrence D, Branch, Donald R, Gallagher, Michael T
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 04.02.1982
• Subjects: Adult; Aged; Anemia; Anemia, Hemolytic, Autoimmune - blood; Anemia, Hemolytic, Autoimmune - immunology; Anemia, Hemolytic, Autoimmune - pathology; Anemia, Hemolytic, Autoimmune - therapy; Antigens; Autoantibodies - immunology; Autoimmune hemolytic anemia; Biopsy; Blood banks; Blood diseases; Blood platelets; Blood transfusions; Bone marrow; Bone Marrow - immunology; Bone Marrow - pathology; Case reports; Complement C3 - analysis; Corticosteroids; Erythrocyte Aging; Erythrocyte Count; Erythrocytes - immunology; Female; Hemolytic anemia; Hospitals; Humans; Hyperplasia; Immunoglobulin G - analysis; Male; Middle Aged; Monocytes; Patients; Reticulocytes; Reticulocytopenia
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM198202043060507

IN the course of a hemolytic disorder, episodes may occur during which reticulocytes virtually disappear from the blood, with the result that uncompensated destruction of red cells leads to progressively severe anemia. "Aplastic crises" were first described in hereditary spherocytosis 1 and have been observed in many other hemolytic states, including autoimmune hemolytic anemia (AIHA). 2 3 4 5 6 7 Often attributable to intercurrent infection, the episodes are usually brief and characterized by transient absence of red-cell precursors from the marrow. In some cases of AIHA, there are prolonged periods of reticulocytopenia, at times accompanied by leukopenia, thrombocytopenia, and hypoplastic marrow. 8 9 10 In other cases, severe reticulocytopenia . . .