Role of glycolytic flux in effect of glucose in decreasing fatty-acid-induced release of lactate dehydrogenase from isolated coronary ligated rat heart

The mechanisms whereby glucose reduces fatty acid-induced release of enzyme from the coronary-ligated isolated perfused working rat heart are investigated. Alterations in the tissue contents of ATP, phosphocreatine, or glycogen could be excluded as possible mechanisms for the beneficial effect of gl...

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Bibliographic Details
Published inCardiovascular research Vol. 13; no. 12; pp. 693 - 702
Main Authors OPIE, LIONEL H., BRICKNELL, OWEN L.
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.12.1979
Subjects
Adenosine Triphosphate - biosynthesis
Albumins - metabolism
Animals
Coronary Disease - enzymology
Coronary Disease - metabolism
Coronary Disease - physiopathology
Depression, Chemical
Glucose - pharmacology
Glycolysis
Heart - drug effects
Insulin - pharmacology
L-Lactate Dehydrogenase - metabolism
Male
Myocardium - enzymology
Myocardium - metabolism
Oxygen Consumption
Palmitates - metabolism
Palmitates - pharmacology
Palmitic Acids - metabolism
Perfusion
Rats
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Summary:The mechanisms whereby glucose reduces fatty acid-induced release of enzyme from the coronary-ligated isolated perfused working rat heart are investigated. Alterations in the tissue contents of ATP, phosphocreatine, or glycogen could be excluded as possible mechanisms for the beneficial effect of glucose in this system. Provision of glycolytic ATP from increased glycolytic flux may be one important factor.
Bibliography:ArticleID:13-12-693
1Request for reprints: Lionel H. Opie M.D., Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa.
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/13.12.693