Role of glycolytic flux in effect of glucose in decreasing fatty-acid-induced release of lactate dehydrogenase from isolated coronary ligated rat heart
The mechanisms whereby glucose reduces fatty acid-induced release of enzyme from the coronary-ligated isolated perfused working rat heart are investigated. Alterations in the tissue contents of ATP, phosphocreatine, or glycogen could be excluded as possible mechanisms for the beneficial effect of gl...
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Published in | Cardiovascular research Vol. 13; no. 12; pp. 693 - 702 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Oxford University Press
01.12.1979
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Subjects | |
Online Access | Get full text |
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Summary: | The mechanisms whereby glucose reduces fatty acid-induced release of enzyme from the coronary-ligated isolated perfused working rat heart are investigated. Alterations in the tissue contents of ATP, phosphocreatine, or glycogen could be excluded as possible mechanisms for the beneficial effect of glucose in this system. Provision of glycolytic ATP from increased glycolytic flux may be one important factor. |
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Bibliography: | ArticleID:13-12-693 1Request for reprints: Lionel H. Opie M.D., Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa. istex:DCDF3B968E447C08C671C93DA6150BA83F697425 ark:/67375/HXZ-8KL0DK2F-Q ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0008-6363 1755-3245 |
DOI: | 10.1093/cvr/13.12.693 |