Effects of Matrix Metalloproteinase Inhibitors on Bone Resorption and Orthodontic Tooth Movement

• Published in: Journal of dental research Vol. 82; no. 9; pp. 687 - 691
• Main Authors: Holliday, L.S., Vakani, A., Archer, L., Dolce, C.
• Format: Journal Article
• Language: English
• Published: United States SAGE Publications 01.09.2003; SAGE PUBLICATIONS, INC
• Subjects: Amides - pharmacology; Amino Acid Sequence; Analysis of Variance; Animals; Bone Marrow Cells - drug effects; Bone Remodeling - drug effects; Bone Resorption - physiopathology; Cell Culture Techniques; Delayed-Action Preparations; Dentistry; Hydroxamic Acids; Indoles - pharmacology; Male; Matrix Metalloproteinase Inhibitors; Maxilla - drug effects; Mice; Oligopeptides - pharmacology; Osteoclasts - drug effects; Polyvinyls; Rats; Rats, Sprague-Dawley; Receptors, Immunologic - physiology; Tooth Movement Techniques; Tyrosine - analogs & derivatives; Tyrosine - pharmacology; matrix metalloproteinase inhibitors; bone resorption; orthodontic tooth movement
• ISSN: 0022-0345; 1544-0591
• DOI: 10.1177/154405910308200906

Matrix metalloproteinases are involved in the regulation of bone remodeling. The hypothesis that matrix metalloproteinase inhibitors may be useful for experimentally limiting orthodontic tooth movement, a process involving perturbations of normal bone remodeling, was tested. General matrix metalloproteinase inhibitors limited the resorption of bone slices by mouse marrow cultures stimulated by calcitriol, parathyroid hormone, and basic-fibroblast growth factor. Pre-coating dentin slices with short arginine-glycine aspartic acid (RGD) peptides, but not arginine-glycine-glutamic acid (RGE) controls, restored bone resorption in the presence of matrix metalloproteinase inhibitors. Orthodontic tooth movement was inhibited by local delivery of Ilomastat, a general matrix metalloproteinase inhibitor, with the use of ethylene-vinyl-acetate (ELVAX) 40, a non-biodegradable, non-inflammatory sustained-release polymer. This study shows that orthodontic tooth movement can be inhibited with the use of matrix metalloproteinase inhibitors, and suggests a mechanistic link between matrix metalloproteinase activity and the production of RGD peptides.