Cellular and molecular mechanisms of cartilage damage and repair

• Published in: Drug discovery today Vol. 19; no. 8; pp. 1172 - 1177
• Main Authors: Sherwood, Joanna C., Bertrand, Jessica, Eldridge, Suzanne E., Dell’Accio, Francesco
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2014
• Subjects: Animals; Arthritis, Rheumatoid - pathology; Arthritis, Rheumatoid - physiopathology; Cartilage - pathology; Cartilage - physiopathology; Chondrocytes - pathology; Chondrocytes - physiology; Humans; Inflammation - pathology; Inflammation - physiopathology; Osteoarthritis - pathology; Osteoarthritis - physiopathology; Wound Healing - physiology

•Cartilage breakdown is the disabling outcome of rheumatic diseases.•Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research.•This review forms part of a supplement on rheumatology. Cartilage breakdown is the disabling outcome of rheumatic diseases, wh...