Cellular and molecular mechanisms of cartilage damage and repair

•Cartilage breakdown is the disabling outcome of rheumatic diseases.•Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research.•This review forms part of a supplement on rheumatology. Cartilage breakdown is the disabling outcome of rheumatic diseases, wh...

Full description

Saved in:
Bibliographic Details
Published inDrug discovery today Vol. 19; no. 8; pp. 1172 - 1177
Main Authors Sherwood, Joanna C., Bertrand, Jessica, Eldridge, Suzanne E., Dell’Accio, Francesco
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2014
Subjects
Animals
Arthritis, Rheumatoid - pathology
Arthritis, Rheumatoid - physiopathology
Cartilage - pathology
Cartilage - physiopathology
Chondrocytes - pathology
Chondrocytes - physiology
Humans
Inflammation - pathology
Inflammation - physiopathology
Osteoarthritis - pathology
Osteoarthritis - physiopathology
Wound Healing - physiology
Online AccessGet full text

Cover

More Information
Summary:•Cartilage breakdown is the disabling outcome of rheumatic diseases.•Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research.•This review forms part of a supplement on rheumatology. Cartilage breakdown is the disabling outcome of rheumatic diseases, whether prevalently inflammatory such as rheumatoid arthritis or prevalently mechanical such as osteoarthritis (OA). Despite the differences between immune-mediated arthritides and OA, common mechanisms drive cartilage breakdown. Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research and will be summarised in this review.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2014.05.014