Cellular and molecular mechanisms of cartilage damage and repair

•Cartilage breakdown is the disabling outcome of rheumatic diseases.•Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research.•This review forms part of a supplement on rheumatology. Cartilage breakdown is the disabling outcome of rheumatic diseases, wh...

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Published inDrug discovery today Vol. 19; no. 8; pp. 1172 - 1177
Main Authors Sherwood, Joanna C., Bertrand, Jessica, Eldridge, Suzanne E., Dell’Accio, Francesco
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2014
Subjects
Animals
Arthritis, Rheumatoid - pathology
Arthritis, Rheumatoid - physiopathology
Cartilage - pathology
Cartilage - physiopathology
Chondrocytes - pathology
Chondrocytes - physiology
Humans
Inflammation - pathology
Inflammation - physiopathology
Osteoarthritis - pathology
Osteoarthritis - physiopathology
Wound Healing - physiology
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Abstract •Cartilage breakdown is the disabling outcome of rheumatic diseases.•Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research.•This review forms part of a supplement on rheumatology. Cartilage breakdown is the disabling outcome of rheumatic diseases, whether prevalently inflammatory such as rheumatoid arthritis or prevalently mechanical such as osteoarthritis (OA). Despite the differences between immune-mediated arthritides and OA, common mechanisms drive cartilage breakdown. Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research and will be summarised in this review.
AbstractList Cartilage breakdown is the disabling outcome of rheumatic diseases, whether prevalently inflammatory such as rheumatoid arthritis or prevalently mechanical such as osteoarthritis (OA). Despite the differences between immune-mediated arthritides and OA, common mechanisms drive cartilage breakdown. Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research and will be summarised in this review.
•Cartilage breakdown is the disabling outcome of rheumatic diseases.•Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research.•This review forms part of a supplement on rheumatology. Cartilage breakdown is the disabling outcome of rheumatic diseases, whether prevalently inflammatory such as rheumatoid arthritis or prevalently mechanical such as osteoarthritis (OA). Despite the differences between immune-mediated arthritides and OA, common mechanisms drive cartilage breakdown. Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research and will be summarised in this review.
Author Sherwood, Joanna C.
Dell’Accio, Francesco
Eldridge, Suzanne E.
Bertrand, Jessica
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/24880104$$D View this record in MEDLINE/PubMed
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Snippet •Cartilage breakdown is the disabling outcome of rheumatic diseases.•Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the...
Cartilage breakdown is the disabling outcome of rheumatic diseases, whether prevalently inflammatory such as rheumatoid arthritis or prevalently mechanical...
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SubjectTerms Animals
Arthritis, Rheumatoid - pathology
Arthritis, Rheumatoid - physiopathology
Cartilage - pathology
Cartilage - physiopathology
Chondrocytes - pathology
Chondrocytes - physiology
Humans
Inflammation - pathology
Inflammation - physiopathology
Osteoarthritis - pathology
Osteoarthritis - physiopathology
Wound Healing - physiology
Title Cellular and molecular mechanisms of cartilage damage and repair
URI https://dx.doi.org/10.1016/j.drudis.2014.05.014
https://www.ncbi.nlm.nih.gov/pubmed/24880104
https://search.proquest.com/docview/1566400507
Volume 19
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