Pyridoxine improves hippocampal cognitive function via increases of serotonin turnover and tyrosine hydroxylase, and its association with CB1 cannabinoid receptor-interacting protein and the CB1 cannabinoid receptor pathway

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 12; pp. 3142 - 3153
• Main Authors: Jung, Hyo Young, Kim, Dae Won, Nam, Sung Min, Kim, Jong Whi, Chung, Jin Young, Won, Moo-Ho, Seong, Je Kyung, Yoon, Yeo Sung, Yoo, Dae Young, Hwang, In Koo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2017
• Subjects: Animals; antagonists; cannabinoids; Carrier Proteins - physiology; CB1 cannabinoid receptor-interacting protein 1; cell proliferation; cognition; Cognition - drug effects; Hippocampus; Hippocampus - drug effects; Hippocampus - physiology; Immunohistochemistry; LIM Domain Proteins - physiology; Male; Memory; Mice; Mice, Inbred C57BL; Neurogenesis; Novel object recognition; protein composition; proteomics; Pyridoxine; Pyridoxine - pharmacology; Receptor, Cannabinoid, CB1 - analysis; Receptor, Cannabinoid, CB1 - physiology; serotonin; Serotonin - metabolism; small interfering RNA; tyrosine; tyrosine 3-monooxygenase; Tyrosine 3-Monooxygenase - analysis; Tyrosine 3-Monooxygenase - metabolism; Pyridoxine; Novel object recognition; CB1 cannabinoid receptor-interacting protein 1; Neurogenesis; Hippocampus

In the present study, we investigated the effects of pyridoxine on hippocampal functions and changes in protein profiles based on the proteomic approach. Eight-week-old mice received intraperitoneal injections of physiological saline (vehicle) or 350mg/kg pyridoxine twice a day for 21days. Phosphogl...