Ocular surface disease incidence in patients with open-angle glaucoma
Ocular surface disease (OSD) is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbances, tear film instability with potential damage to the ocular surface, accompanied by increased tear film osmolarity and inflammation of the ocular surfac...
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Published in | Srpski arhiv za celokupno lekarstvo Vol. 144; no. 7-8; pp. 376 - 383 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Serbia
Serbian Medical Society
01.07.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Ocular surface disease (OSD) is a multifactorial disease of the tears and ocular surface that
results in symptoms of discomfort, visual disturbances, tear film instability with potential damage to the
ocular surface, accompanied by increased tear film osmolarity and inflammation of the ocular surface. It is
a consequence of disrupted homeostasis of lacrimal functional unit. The main pathogenetic mechanism
stems from tear hyperosmolarity and tear film instability. The etiological classification is hyposecretory
(Sy-Sjögren and non-Sjögren) and evaporative (extrinsic and intrinsic) form. Delphi panel classification
grades disease stages. Antiglaucoma topical therapy causes exacerbation or occurrence of symptoms
of dry eye due to main ingredients or preservatives (benzalkonium chloride – BAK), which are dose- and
time-dependent. BAK reduces the stability of the lipid layer of tears, the number of goblet cells, induces
apoptosis and inflammatory infiltration.
The aim of this study was the analysis of the OSD incidence in open-angle glaucoma patients
caused by topical medicamentous therapy.
Retrospective analysis of examined patients with open-angle glaucoma was used.
Increased incidence of moderate and advanced OSD Index degrees in the group of primary
open-angle glaucoma (POAG) and pseudoexfoliative glaucoma. According to the Delphi Panel Scale the
most common grade is IIb (POAG and pseudoexfoliative glaucoma). Evaporative form of OSD prevailed
in all treatment groups. High percentage of dry eye in patients with higher concentrations of preservatives
applied was noticed.
OSD should be timely diagnosed and treated. Dry eye has an impact on surgical outcome
and postoperative visual acuity, and in order to improve patient compliance and quality of life, symptoms
of dry eye should be addressed and medications with lower concentrations of preservatives should be
applied. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0370-8179 2406-0895 |
DOI: | 10.2298/SARH1608376R |