Systemic scleroderma and perforating granuloma annulare: differential diagnosis from calcinosis

Systemic scleroderma is a disorder of unknown etiology with skin sclerosis. Its major histological features are swollen and homogenized collagen bundles. We describe 2 patients with systemic sclerosis who have multiple umbilicated nodules indistinguishable from calcinosis cutis. Histological examina...

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Bibliographic Details
Published inDermatology (Basel) Vol. 192; no. 3; p. 271
Main Authors Tajima, S, Suzuki, Y, Inazumi, T, Mori, N
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1996
Subjects
Adult
Calcinosis - diagnosis
Calcinosis - pathology
Diagnosis, Differential
Female
Fingers
Granuloma Annulare - complications
Granuloma Annulare - diagnosis
Granuloma Annulare - physiopathology
Humans
Scleroderma, Systemic - complications
Scleroderma, Systemic - diagnosis
Scleroderma, Systemic - physiopathology
Skin Diseases - diagnosis
Skin Diseases - pathology
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Summary:Systemic scleroderma is a disorder of unknown etiology with skin sclerosis. Its major histological features are swollen and homogenized collagen bundles. We describe 2 patients with systemic sclerosis who have multiple umbilicated nodules indistinguishable from calcinosis cutis. Histological examinations including Von Kossa staining revealed features of perforating granuloma annulare, but not of calcinosis cutis. The association may not be fortuitous but both diseases may be etiologically related.
ISSN:1018-8665
DOI:10.1159/000246383