Well-defined core-shell nanoparticles containing cyclodextrin in the shell: A comprehensive study

• Published in: Polymer (Guilford) Vol. 52; no. 17; pp. 3752 - 3761
• Main Authors: El Fagui, Amani, Dalmas, Florent, Lorthioir, Cédric, Wintgens, Véronique, Volet, Gisèle, Amiel, Catherine
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 03.08.2011; Elsevier
• Subjects: Adsorption; Applied sciences; Biological and medical sciences; Core-shell nanoparticles; Cyclodextrin polymer; Cyclodextrins; drug delivery systems; Dynamical systems; Dynamics; Exact sciences and technology; Forms of application and semi-finished materials; General pharmacology; hydrophobicity; lactic acid; light scattering; Medical sciences; Miscellaneous; Nanoparticles; Nanostructure; nuclear magnetic resonance spectroscopy; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; PLA; Polymer industry, paints, wood; polymers; Shells; Surface chemistry; Technology of polymers; transmission electron microscopy; zeta potential; PLA; Core-shell nanoparticles; Cyclodextrin polymer; Branched polymer; Chemical precipitation; Liquid solid adsorption; Nanoparticle; Control release polymer; Core shell structure; Drug carrier; Experimental study; Property processing relationship; Layer thickness; Cyclodextrin; Particle size distribution; Lactic acid polymer; Adsorbed layers; Morphology; Cyclodextrin derivative; Oside polymer; Electrokinetic potential; Manufacturing; Growth from solution
• ISSN: 0032-3861; 1873-2291
• DOI: 10.1016/j.polymer.2011.06.043

The purpose of this study was to conceive novel nanoparticles (NPs) designed for drug delivery applications. The NPs were based on a hydrophobic poly (lactic acid) (PLA) core and a hydrophilic β-cyclodextrin polymer (Poly-β-CD) shell. The PLA NPs were prepared by the nanoprecipitation method. The Poly-β-CD shell was obtained by adsorption from Poly-β-CD solution. Different complementary techniques have been used to fully characterize the system including dynamic light scattering, Zeta potential measurements, solution proton nuclear magnetic resonance spectroscopy, transmission electron microscopy, and small angle neutron scattering. They provide good evidence of a core-shell structure. The NPs parameters are dependent on the elaboration process, Poly-β-CD characteristics and adsorption conditions. In the conditions of adsorption’ saturation, the shells were constituted of Poly-β-CD monolayers covering the PLA surfaces with adsorption amounts from 2 to 4 mg/m 2, allowing reaching Poly-β-CD weight fractions of 10–20% in the NPs. [Display omitted]