Primary esophageal diffuse large B-cell lymphoma: Report of a case

Primary esophageal lymphoma is very rare, with fewer than 25 cases documented in the English-language literature. We report a case of primary diffuse large B-cell lymphoma of the esophagus in a 42-year-old woman. Barium esophagogram revealed almost complete esophageal obstruction at the level of the...

Full description

Saved in:
Bibliographic Details
Published inSurgery today (Tokyo, Japan) Vol. 38; no. 7; pp. 647 - 650
Main Authors Sabljak, Predrag, Stojakov, Dejan, Bjelovic, Milos, Mihaljevic, Biljana, Velickovic, Dejan, Ebrahimi, Keramatollah, Spica, Bratislav, Peško, Predrag
Format Journal Article
LanguageEnglish
Published Japan Springer Japan 01.07.2008
Subjects
Adult
Aphasia - etiology
Case Report
Esophageal Neoplasms - diagnosis
Esophageal Neoplasms - drug therapy
Esophageal Neoplasms - pathology
Female
Humans
Lymphoma, Large B-Cell, Diffuse - diagnosis
Lymphoma, Large B-Cell, Diffuse - drug therapy
Lymphoma, Large B-Cell, Diffuse - pathology
Medicine
Medicine & Public Health
Surgery
Surgical Oncology
Treatment Outcome
Neoplasm
Therapy
Diagnosis
Lymphoma
Esophagus
Online AccessGet full text

Cover

More Information
Summary:Primary esophageal lymphoma is very rare, with fewer than 25 cases documented in the English-language literature. We report a case of primary diffuse large B-cell lymphoma of the esophagus in a 42-year-old woman. Barium esophagogram revealed almost complete esophageal obstruction at the level of the cervical esophagus, and flexible endoscopy showed a circumferential submucosal tumor covered with intact mucosa. Neck magnetic resonance imaging (MRI) showed a wide cervical mass circumferentially encompassing the lumen of the cervical esophagus. Biopsies taken with multiple forceps during flexible and rigid esophagoscopy were nondiagnostic. Finally, external esophageal wall biopsies taken during neck exploration provided information that helped us establish the diagnosis. Pathohistological findings confirmed non-Hodgkin’s lymphoma of the diffuse large B-cell type. The patient was treated with combined immunochemotherapy, consisting of rituximab plus cyclophosphamide, vincristine, adriablastin, and prednisone (CHOP), followed by irradiation. A complete response was achieved, and 3 years after diagnosis and treatment the patient was disease-free.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-007-3690-6