Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of , a molecule indispensable for lipid endocytosis and regulatio...

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Published inFrontiers in immunology Vol. 13; p. 869042
Main Authors Zaffina, Salvatore, Piano Mortari, Eva, Di Prinzio, Reparata Rosa, Cappa, Marco, Novelli, Antonio, Agolini, Emanuele, Raponi, Massimiliano, Dallapiccola, Bruno, Locatelli, Franco, Perno, Carlo Federico, Carsetti, Rita
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 06.04.2022
Subjects
Adenovirus Vaccines
BNT162 Vaccine
case report
CAVIN1
congenital generalized lipodystrophy type 4
COVID-19
COVID-19 Vaccines - adverse effects
Humans
Immunology
Lipodystrophy, Congenital Generalized
Liposomes
memory B cells
Middle Aged
Nanoparticles
SARS-CoV-2
SARS-CoV-2 vaccine
Vaccination
SARS-CoV-2 vaccine
case report
congenital generalized lipodystrophy type 4
CAVIN1
memory B cells
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Summary:A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of , a molecule indispensable for lipid endocytosis and regulation, we complemented the vaccination cycle with a single dose of the Ad26.COV2 vaccine. Adenovirus-based vaccine entry is mediated by the interaction with adenovirus receptors and transport occurs in clathrin-coated pits. Ten days after Ad26.COV2 administration, S- and RBD-specific antibodies and high-affinity memory B cells increased significantly to values close to those observed in Health Care Worker controls.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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Edited by: Kim Good-Jacobson, Monash University, Australia
This article was submitted to Immunological Memory, a section of the journal Frontiers in Immunology
Reviewed by: Arantzazu Alfranca, Hospital de la Princesa, Spain; Stephen Rawlings, University of California, San Diego, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.869042