Comparison of maximal Rubidium-82 activities for myocardial blood flow quantification between digital and conventional PET systems

• Published in: Journal of nuclear cardiology Vol. 26; no. 4; pp. 1286 - 1291
• Main Authors: van Dijk, Joris D., Jager, Pieter L., van Osch, Jochen A.C., Khodaverdi, Maryam, van Dalen, Jorn A.
• Format: Journal Article
• Language: English
• Published: Cham Elsevier Inc 01.08.2019; Springer International Publishing; Springer Nature B.V
• Subjects: Accuracy; ANALOG SYSTEMS; Bias; BLOOD FLOW; Brief Report; cardiac positron emission tomography; Cardiology; COMPARATIVE EVALUATIONS; Coronary Circulation - physiology; Digital PET; direct photon counting; dynamic range; Hospitals; Humans; Image Processing, Computer-Assisted; Imaging; Medicine; Medicine & Public Health; Nuclear Medicine; Patients; PHANTOMS; Phantoms, Imaging; PHOTON COUNTING; POSITRON COMPUTED TOMOGRAPHY; Positron-Emission Tomography; Radiology; RADIOLOGY AND NUCLEAR MEDICINE; Reproducibility of Results; RUBIDIUM 82; Rubidium Radioisotopes; Scanners; Tomography; MBF; CT; direct photon counting; rubidium-82; cardiac positron emission tomography; dynamic range; Digital PET; COV; PET
• ISSN: 1071-3581; 1532-6551; 1532-6551
• DOI: 10.1007/s12350-017-1156-9

PET-based myocardial blood flow (MBF) quantification can be inaccurate when using high tracer activities. Our aim was to derive the maximal Rubidium-82 activity for MBF assessment using a new digital PET system and compare the results with conventional analog systems. 1.8 GBq Rubidium-82 was injected into the cardiac insert of an anthropomorphic torso phantom. Data were acquired for 10 min using an Ingenuity TF (Philips Healthcare), Discovery 690 (D690, GE Healthcare), and digital PET prototype system (Philips Healthcare). The dynamic ranges, defined as the maximal measured activity in the reconstructed images deviating < 10% from the true present activity, were determined in all scans. The dynamic ranges were 312 MBq for Ingenuity TF, 650 MBq for D690, and 654 MBq for digital PET prototype. The maximal Rb-82 activity for MBF assessment using digital PET prototype is higher than that for its analog counterpart (Ingenuity TF), but seems comparable to the D690.