Determination of Rifampicin by Peroxomonosulfate-Cobalt(II) Chemiluminescence System

• Published in: Chinese journal of chemistry Vol. 26; no. 5; pp. 905 - 910
• Main Authors: MA, Yong, ZHANG, Bo-Tao, ZHAO, Li-Xia, GUO, Guang-Sheng, LIN, Jin-Ming
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.05.2008; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: chemiluminescence; cobalt(II); flow injection analysis; peroxomonosulfate; rifampicin
• ISSN: 1001-604X; 1614-7065
• DOI: 10.1002/cjoc.200890166

Rifampicin can enhance the chemiluminescence (CL) of peroxomonosulfate‐cobalt(II) system, and the CL intensity is strongly dependent on the rifampicin concentrations. Based on this phenomenon, a rapid and sensitive flow injection CL method was developed for the determination of rifampicin. The relative CL intensity was linear with the rifampicin concentration over the range of 5×10−8 to 1×10−6 g·mL−1 (r=0.9991), the detection limit was 7×10−9 g·mL−1 (S/N=3), and the relative standard deviation was 2.7% for 6×10−7 g·mL−1 rifampicin (n=11). Furthermore, this method was successfully applied to the determination of rifampicin in real eye drop and capsules sample.