Lacticacidosis after short‐term infusion of propofol for anaesthesia in a child with osteogenesis imperfecta

• Published in: Pediatric anesthesia Vol. 13; no. 9; pp. 823 - 826
• Main Authors: Kill, Clemens, Leonhardt, Andreas, Wulf, Hinnerk
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.11.2003; Blackwell
• Subjects: Acidosis, Lactic - blood; Acidosis, Lactic - chemically induced; anaesthesia; Anesthesia, Intravenous - adverse effects; Anesthetics, Intravenous - adverse effects; Biological and medical sciences; Child; Dose-Response Relationship, Drug; Drug toxicity and drugs side effects treatment; Fasting - metabolism; Femoral Fractures - complications; Femoral Fractures - surgery; Fentanyl - administration & dosage; Hemodynamics - drug effects; Humans; Lactic Acid - blood; lacticacidosis; Male; Medical sciences; Miscellaneous (drug allergy, mutagens, teratogens...); Neuromuscular Nondepolarizing Agents - administration & dosage; osteogenesis imperfecta; Osteogenesis Imperfecta - complications; Pharmacology. Drug treatments; profol infusion syndrome; propofol; Propofol - adverse effects; Succinylcholine - administration & dosage; Time Factors; Human; Short term; Intravenous administration; Toxicity; Diseases of the osteoarticular system; General anesthesia; Acid base balance disorder; Genetic disease; Case study; Metabolic disorder; General anesthetic; Perfusion; lacticacidosis; Osteogenesis imperfecta; Complication; Lactic acid; Propofol; Acidosis; profol infusion syndrome; Osteochondrodysplasia; Child; anaesthesia
• ISSN: 1155-5645; 1460-9592
• DOI: 10.1046/j.1460-9592.2003.01114.x

Summary We describe the case of a 7‐year‐old boy with osteogenesis imperfecta, who underwent anaesthesia with propofol–fentanyl–nitrous oxide–suxamethonium for orthopaedic surgery of a distal femur fracture. He developed lacticacidosis after short‐term propofol infusion (150 min, mean infusion rate 13.5 mg·kg−1·h−1) associated with a prolonged recovery time without serious haemodynamic changes. The highest lactate concentration was 9.2 mmol·l−1 at 160 min after discontinuation of propofol. There was no significant increase in body temperature. The boy fully recovered.