Microvascular changes in the peripheral microcirculation of women with chronic pelvic pain due to congestion

• Published in: BJOG : an international journal of obstetrics and gynaecology Vol. 109; no. 8; pp. 867 - 873
• Main Authors: Foong, L.C., Gamble, J., Sutherland, I.A., Beard, R.W.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.08.2002; Blackwell
• Subjects: Adult; Aged; Biological and medical sciences; Blood Pressure - physiology; Chronic Disease; Extremities - blood supply; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Longitudinal Studies; Medical sciences; Microcirculation - physiology; Middle Aged; Non tumoral diseases; Pelvic Pain - physiopathology; Peripheral Vascular Diseases - physiopathology; Prospective Studies; Human; Microcirculation; Chronic; Menstrual cycle; Pathogenesis; Pelvis pathology; Adult; Female; Pelvic pain; Elderly; Plethysmography; Venous pressure
• ISSN: 1470-0328; 1471-0528
• DOI: 10.1111/j.1471-0528.2002.01424.x

Objective Pelvic venous congestion is a common finding in women with chronic pelvic pain. While the pathophysiology of this condition is poorly understood, there are clear indications that it involves vascular dysfunction. The present studies sought abnormalities in microvascular function in these patients. Design Prospective longitudinal study. Setting A teaching hospital tertiary referral. Population Eighteen women with pelvic congestion and 13 nomal women. Methods Parameters of microcirculatory function were measured in the calves of women using venous congestion plethysmography during the midfollicular and midluteal phases of the menstrual cycle. The women with pelvic congestion were studied again after treatment for the condition. Main outcome measures Isovolumetric venous pressure, microvascular filtration capacity and limb blood flow. Results Of the measured parameters of microvascular function, only isovolumetric venous pressure (Pvi) was significantly higher in women with congestion when compared to the controls during the same phase of the cycle. There were no menstrual cycle related differences in any of the other measured parameters in either patients or controls. Following successful treatment for the condition, values of Pvi in women with pelvic congestion were significantly reduced, achieving a level similar to that observed in the controls. Conclusion The observed changes in Pvi suggest that this parameter is intimately associated with the pathophysiology of pelvic congestion. The increase in Pvi, without alterations in other measured microvascular parameters, may be attributable to systemic increases in postcapillary resistance secondary to neutrophil activation. These findings support the notion of systemic microvascular dysfunction in these women.