Neural stem cells, adult neurogenesis, and galectin‐1: From bench to bedside

• Published in: Developmental neurobiology (Hoboken, N.J.) Vol. 72; no. 7; pp. 1059 - 1067
• Main Authors: Sakaguchi, Masanori, Okano, Hideyuki
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2012
• Subjects: adult NSCs; Adult Stem Cells - cytology; Adult Stem Cells - metabolism; Adult Stem Cells - transplantation; Animals; Dentate Gyrus - cytology; Dentate Gyrus - metabolism; Galectin; Galectin 1 - metabolism; Memory - physiology; Neural Stem Cells - cytology; Neural Stem Cells - metabolism; Neural Stem Cells - transplantation; Neurogenesis - physiology; Neurons - cytology; Neurons - metabolism; Neurons - transplantation; regeneration; SVZ
• ISSN: 1932-8451; 1932-846X
• DOI: 10.1002/dneu.22023

Neural stem cells (NSCs) in the adult brain have been a consistent focus of biomedical research largely because of their potential clinical application. To fully exploit this potential, the molecular mechanisms that regulate NSCs must be clarified. Several lines of evidence show that a multifunctional protein, Galectin‐1, is expressed and has a functional role in a subset of adult NSCs. Researchers, including our group, have explored the physiological role of Galectin‐1 in NSCs and its application in the treatment of animal models of neurological disorders such as brain ischemia and spinal cord injury. Here, we summarize what is currently known regarding the role of Galectin‐1 in adult NSCs. Furthermore, we discuss current issues in researching the role of Galectin‐1 in adult NSCs under both physiological and pathological conditions. © 2012 Wiley Periodicals, Inc. Develop Neurobiol 72: 1059–1067, 2012