Diagnostic Evaluation on Cerebral Hemisphere Scintigraphy Using 99mTc-MAA

• Published in: RADIOISOTOPES Vol. 28; no. 9; pp. 551 - 557
• Main Authors: KAKUDA, Takami, ONO, Motoaki, YAMASHITA, Kazuyoshi, ITO, Hideaki, SAWAI, Yumi, YAGURA, Michio, MORISHIGE, Fukumi, KOTANI, Sumio, SAWADA, Osamu, MORISHIGE, Tatsumi, FUGII, Terumi, MIYAHATA, Minako, USHIO, Bunichi
• Format: Journal Article
• Language: Japanese
• Published: Japan Japan Radioisotope Association 15.09.1979
• Subjects: Adult; Aged; Albumins; Brain - diagnostic imaging; cerebral blood flow distribution; cerebral hemisphere scintigraphy; cerebrovascular disease; Cerebrovascular Disorders - diagnostic imaging; Child; Evaluation Studies as Topic; Female; Humans; macroaggregated albumin; Male; Middle Aged; Radionuclide Imaging; Technetium
• ISSN: 0033-8303; 1884-4111
• DOI: 10.3769/radioisotopes.28.9_551

Using 99mTc-labeled macroaggregated albumin (99mTc-MAA), we made an examination of the cerebral blood flow distribution with various kinds of cerebrovascular diseases in 151 cases. The particle size of MAA used in this study ranged from 10 to 100 μm. Scan was performed after injection of 3 mGi of 99mTc-MAA into common carotid artery. No side effects were observed except for one case with headache. Distribution of 99mTc-MAA was found to be homogeneous in normal cerebral hemisphere but not in the lesion. Most lesion was shown as nonradioactive area. Meningioma with hy-pervascularity was represented as hot area. By this method cerebral infarct could be easily represented not only in main artery but also in such a very small artery as hardly detected by GAG. This method is therefore useful for detecting cerebral infarct, sequela of cerebral apoplexy, head injury and others. The dose of 99mTc-MAA used in this method is much lower compared with those of common brain scan, its excretion is speedy, and therefore internal radiation exposure is diminished.