Researches on Chemotherapeutic Drugs against Viruses. XXXII. Studies on the Synthesis and the Antiviral Effect of N-Alkanoyl-5-acetamido-8-quinolinesulfonamide

The six compounds of N-alkanoyl-5-acetamido-8-quinolinesulfonamide were synthesized and their antiviral effect was tested by employing the Nakayama strain of Japanese B encephalitis virus. The decanoyl derivative was more effective in vitro than PANS-610 or N-decanoyl-8-ethoxy-5-quinolinesulfonamide...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 8; no. 10; pp. 930 - 932
Main Authors Kawahata, Junzo, Koibuchi, Hiroko, Toyoshima, Shigeshi
Format Journal Article
LanguageEnglish
Published The Pharmaceutical Society of Japan 1960
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Summary:The six compounds of N-alkanoyl-5-acetamido-8-quinolinesulfonamide were synthesized and their antiviral effect was tested by employing the Nakayama strain of Japanese B encephalitis virus. The decanoyl derivative was more effective in vitro than PANS-610 or N-decanoyl-8-ethoxy-5-quinolinesulfonamide. Moreover, the decanoyl derivative was found to possess significant in vivo effect against the Nakayama strain.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.8.930