Four new fatty acid derivatives from Diaporthe sp. T24, an endophytic fungus isolated from Ligularia fischer

• Published in: Journal of asian natural products research Vol. 24; no. 7; pp. 603 - 616
• Main Authors: He, Min, Yin, Wan-Qiang, Sun, Hai-Feng, Ding, Yu-Wei, Xu, Shuai, Sun, Hua, Wang, Jia-Ming, Yu, Peng, Qin, Hai-Juan, Chen, Ming-Hua
• Format: Journal Article
• Language: English
• Published: ABINGDON Taylor & Francis 03.07.2022; Taylor & Francis Ltd
• Subjects: absolute configuration; Chemistry; Chemistry, Applied; Chemistry, Medicinal; Coupling (molecular); cytotoxic effect; Cytotoxicity; Diaporthe; Endophytes; endophytic fungus; Fatty acid; Fatty acids; Fungi; Life Sciences & Biomedicine; Metabolites; Pharmacology & Pharmacy; Physical Sciences; Plant Sciences; Science & Technology; Secondary metabolites; Selectivity; METABOLITES; endophytic fungus; secondary metabolites; absolute configuration; cytotoxic effect; Fatty acid
• ISSN: 1028-6020; 1477-2213
• DOI: 10.1080/10286020.2021.1962309

The endophytic fungus Diaporthe sp. is known to contain many secondary metabolites, but fatty acid derivatives have rarely been found. In this study, four new fatty acid derivatives (1-4), together with four known compounds (5-8), were isolated from Diaporthe sp., which was obtained from the stem of Ligularia fischeri. The absolute configurations of the new compounds 1-4 were deduced based on spectroscopic technique and J-based coupling constant analysis. Moreover, compound 1 exhibited cytotoxic activities against HCT-8 and MCF-7 cancer cells, and compounds 3 and 4 showed modest selectivity for HCT-8 cells by MTT assay.