A multifunctional metal-organic framework based tumor targeting drug delivery system for cancer therapy

Drug delivery systems (DDSs) with biocompatibility and precise drug delivery are eagerly needed to overcome the paradox in chemotherapy that high drug doses are required to compensate for the poor biodistribution of drugs with frequent dose-related side effects. In this work, we reported a metal-org...

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Published inNanoscale Vol. 7; no. 38; pp. 16061 - 16070
Main Authors Wang, Xiao-Gang, Dong, Zhi-Yue, Cheng, Hong, Wan, Shuang-Shuang, Chen, Wei-Hai, Zou, Mei-Zhen, Huo, Jia-Wei, Deng, He-Xiang, Zhang, Xian-Zheng
Format Journal Article
LanguageEnglish
Published England 14.10.2015
Subjects
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Bonding
Cancer
Cellular
Cercopithecus aethiops
COS Cells
Drug Delivery Systems
Drugs
HeLa Cells
Humans
Metal-organic frameworks
Nanoparticles
Nanostructure
Side effects
Tissue Distribution
Tumors
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Summary:Drug delivery systems (DDSs) with biocompatibility and precise drug delivery are eagerly needed to overcome the paradox in chemotherapy that high drug doses are required to compensate for the poor biodistribution of drugs with frequent dose-related side effects. In this work, we reported a metal-organic framework (MOF) based tumor targeting DDS developed by a one-pot, and organic solvent-free "green" post-synthetic surface modification procedure, starting from the nanoscale MOF MIL-101. Owing to the multifunctional surface coating, premature drug release from this DDS was prevented. Due to the pH responsive benzoic imine bond and the redox responsive disulfide bond at the modified surface, this DDS exhibited tumor acid environment enhanced cellular uptake and intracellular reducing environment triggered drug release. In vitro and in vivo results showed that DOX loaded into this DDS exhibited effective cancer cell inhibition with much reduced side effects.
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ISSN:2040-3364
2040-3372
DOI:10.1039/c5nr04045k