Adipocyte fatty acid binding protein during refeeding of female patients with anorexia nervosa

• Published in: European journal of nutrition Vol. 48; no. 7; pp. 403 - 408
• Main Authors: Engl, Julia, Tschoner, Alexander, Willis, Michael, Schuster, Ingrid, Kaser, Susanne, Laimer, Markus, Biebl, Wilfried, Patsch, Josef R, Mangweth, Barbara, Ebenbichler, Christoph F
• Format: Journal Article
• Language: English
• Published: Heidelberg Heidelberg : D. Steinkopff-Verlag 01.10.2009; D. Steinkopff-Verlag; Springer Nature B.V
• Subjects: Adipocytes - enzymology; Adolescent; Adult; Anorexia Nervosa - blood; Anorexia Nervosa - diet therapy; Body Composition; Body Mass Index; Bulimia Nervosa - blood; Bulimia Nervosa - diet therapy; Chemistry; Chemistry and Materials Science; Electric Impedance; Enzyme-Linked Immunosorbent Assay; Fatty Acid-Binding Proteins - blood; Female; Humans; Leptin - blood; Matched-Pair Analysis; Middle Aged; Nutrition; Original Contribution; Regression Analysis; Weight Gain; Young Adult; A-FABP; Anorexia nervosa; Metabolism; Weight gain
• ISSN: 1436-6207; 1436-6215
• DOI: 10.1007/s00394-009-0027-9

Background Adipocyte fatty acid binding protein (A-FABP) has been suggested to play an important role in fat metabolism linking obesity and the metabolic syndrome. Increasing A-FABP plasma levels were observed during greatest weight loss after bariatric surgery suggesting that A-FABP may indicate changes in fat mass in dynamic situations. Aim of the study As there are no data on weight gain, we investigated the effect of refeeding anorexic patients on body composition and A-FABP plasma levels. Methods Parameters of glucose and lipid metabolism as well as plasma levels of leptin and A-FABP were prospectively assessed in 16 female patients with anorexia nervosa during inpatient weight restoration. Body composition was determined by multifrequency body impedance analysis. Results After 28 days, fat mass increased from 4.4 ± 2.5 kg at baseline to 5.5 ± 2.2 kg (P < 0.01), constituting 40% of total weight gain. Conversely, A-FABP concentrations decreased from 32.56 ± 35.59 ng/ml at baseline to 21.27 ± 13.68 ng/ml (P < 0.05), which corresponds to a significant decrease in the proportion of A-FABP per kilogram fat mass from 7.86 ± 5.23 to 4.09 ± 2.12 ng/ml/kg (P <= 0.001). Variation in A-FABP plasma concentration was predictive for changes in total cholesterol levels (adjusted r ² = 0.239; P <= 0.05), but not for gain in weight, fat mass, or percent body fat. Conclusion The present results indicate that variation in A-FABP plasma levels reflect alterations in nutritional status in patients with anorexia nervosa.