Posterior syphilitic uveitis: clinical characteristics, co-infection with HIV, response to treatment

• Published in: Japanese journal of ophthalmology Vol. 55; no. 5; pp. 486 - 494
• Main Authors: Li, Sing Your, Birnbaum, Andrea D., Tessler, Howard H., Goldstein, Debra A.
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.09.2011; Springer Nature B.V
• Subjects: Administration, Oral; Adult; Aged; Antiretroviral Therapy, Highly Active; Clinical Investigation; Coinfection; Doxycycline - administration & dosage; Drug Therapy, Combination; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - physiopathology; Homosexuality, Male; Humans; Injections, Intramuscular; Male; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Optic Neuritis - complications; Optic Neuritis - drug therapy; Optic Neuritis - physiopathology; Penicillin G - administration & dosage; Retinitis - complications; Retinitis - drug therapy; Retinitis - physiopathology; Retrospective Studies; Syphilis - complications; Syphilis - drug therapy; Syphilis - physiopathology; Syphilis Serodiagnosis; Uveitis, Posterior - complications; Uveitis, Posterior - drug therapy; Uveitis, Posterior - physiopathology; Visual Acuity - physiology; AIDS; Retinitis; HIV; Syphilis; Optic neuritis; Uveitis
• ISSN: 0021-5155; 1613-2246
• DOI: 10.1007/s10384-011-0053-z

Purpose To describe the characteristics and clinical course of patients with active posterior syphilitic uveitis evaluated between 1991 and 2009. Methods Retrospective chart review. Results Thirteen patients with active posterior syphilitic uveitis were identified at a single institution. All were men, and all with available data were men having sex with men (MSM). Ten of 12 (83%) with available data were HIV positive. Four (31%) had a history of syphilis. Clinical findings included infiltrative retinitis, necrotizing retinitis and optic neuritis. Two of 8 patients tested (25%) had a positive Venereal Disease Research Laboratory test in the cerebrospinal fluid. Treatments included intravenous penicillin, intramuscular penicillin and intramuscular ceftriaxone. All treated cases improved and, in some cases, inflammatory lesions completely resolved without scarring. Conclusions In this series, syphilitic posterior uveitis presented only in men, and all with available data were MSM. The majority were concomitantly infected with HIV. Clinical presentations varied and all patients demonstrated either significant improvement or complete resolution of inflammation.