Potential antithrombotic effect of two new phenylpropanoid sucrose esters and other secondary metabolites of Canna indica L. rhizome
Canna indica L. has been traditionally used to treat various diseases. Based on previously reported antithrombotic effect for this plant, two new phenylpropanoid sucrose esters (canindicoside A (1) and canindicoside B (2)) and seven known compounds: nepetoidin B (3), caffeic acid (4), ferulic acid (...
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Published in | Natural product research Vol. 38; no. 6; pp. 897 - 905 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Taylor & Francis
18.03.2024
Taylor & Francis Ltd |
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Abstract | Canna indica L. has been traditionally used to treat various diseases. Based on previously reported antithrombotic effect for this plant, two new phenylpropanoid sucrose esters (canindicoside A (1) and canindicoside B (2)) and seven known compounds: nepetoidin B (3), caffeic acid (4), ferulic acid (5), (R)-(+)-rosmarinic acid (6), isorinic acid (7), (S)-(-)-rosmarinic acid (8) and (S)-(-)-rosmarinic acid methyl ester (9) were isolated from the ethyl acetate extract. Compounds were elucidated by NMR and MS spectroscopic methods. The antiplatelet effect was evaluated using turbidimetric method. Anticoagulant activity was examined by measuring activated partial thromboplastine time (APTT), prothrombin time, and thrombine time (TT). It was shown for the first time that both new phenylpropanoid sucrose esters 1 and 2, 7 and 9 displayed dose-dependent antiplatelet effects. 2 and 9 had the highest inhibitory activity on both adenosine diphosphate (ADP)- and collagen-induced platelet aggregation. Moreover, 1, 7 and 9 also exhibited anticoagulant activity. At 0.4 mg/mL, both 1 and 7 prolonged APTT compared to the negative control (p < 0.05), suggesting the possible inhibitory impact on the intrinsic coagulation pathway. Moreover, 9 at 0.4 mg/mL exerted higher TT values than the negative control (p < 0.05). C. indica and its bioactive phytochemicals are potential candidates for development of anti-thrombosis therapy. |
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AbstractList | L. has been traditionally used to treat various diseases. Based on previously reported antithrombotic effect for this plant, two new phenylpropanoid sucrose esters (canindicoside A (
) and canindicoside B (
)) and seven known compounds: nepetoidin B (
, caffeic acid (
), ferulic acid (
), (
-(+)-rosmarinic acid (
), isorinic acid (
), (
-(-)-rosmarinic acid (
) and (
)-(-)-rosmarinic acid methyl ester (
) were isolated from the ethyl acetate extract. Compounds were elucidated by NMR and MS spectroscopic methods. The antiplatelet effect was evaluated using turbidimetric method. Anticoagulant activity was examined by measuring activated partial thromboplastine time (APTT), prothrombin time, and thrombine time (TT). It was shown for the first time that both new phenylpropanoid sucrose esters
and
,
and
displayed dose-dependent antiplatelet effects.
and
had the highest inhibitory activity on both adenosine diphosphate (ADP)- and collagen-induced platelet aggregation. Moreover,
,
and
also exhibited anticoagulant activity. At 0.4 mg/mL, both
and
prolonged APTT compared to the negative control (
< 0.05), suggesting the possible inhibitory impact on the intrinsic coagulation pathway. Moreover,
at 0.4 mg/mL exerted higher TT values than the negative control (
< 0.05).
and its bioactive phytochemicals are potential candidates for development of anti-thrombosis therapy. Canna indica L. has been traditionally used to treat various diseases. Based on previously reported antithrombotic effect for this plant, two new phenylpropanoid sucrose esters (canindicoside A (1) and canindicoside B (2)) and seven known compounds: nepetoidin B (3), caffeic acid (4), ferulic acid (5), (R)-(+)-rosmarinic acid (6), isorinic acid (7), (S)-(-)-rosmarinic acid (8) and (S)-(-)-rosmarinic acid methyl ester (9) were isolated from the ethyl acetate extract. Compounds were elucidated by NMR and MS spectroscopic methods. The antiplatelet effect was evaluated using turbidimetric method. Anticoagulant activity was examined by measuring activated partial thromboplastine time (APTT), prothrombin time, and thrombine time (TT). It was shown for the first time that both new phenylpropanoid sucrose esters 1 and 2, 7 and 9 displayed dose-dependent antiplatelet effects. 2 and 9 had the highest inhibitory activity on both adenosine diphosphate (ADP)- and collagen-induced platelet aggregation. Moreover, 1, 7 and 9 also exhibited anticoagulant activity. At 0.4 mg/mL, both 1 and 7 prolonged APTT compared to the negative control (p < 0.05), suggesting the possible inhibitory impact on the intrinsic coagulation pathway. Moreover, 9 at 0.4 mg/mL exerted higher TT values than the negative control (p < 0.05). C. indica and its bioactive phytochemicals are potential candidates for development of anti-thrombosis therapy. |
Author | Nguyen, Thi Van Anh Nguyen, Thi Minh Hang Le, Hong Luyen Bui, Duc Huy |
Author_xml | – sequence: 1 givenname: Thi Van Anh surname: Nguyen fullname: Nguyen, Thi Van Anh organization: Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology – sequence: 2 givenname: Thi Minh Hang surname: Nguyen fullname: Nguyen, Thi Minh Hang organization: Center of Drug Research and Development, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology – sequence: 3 givenname: Hong Luyen surname: Le fullname: Le, Hong Luyen organization: Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology – sequence: 4 givenname: Duc Huy surname: Bui fullname: Bui, Duc Huy organization: Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology |
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Snippet | Canna indica L. has been traditionally used to treat various diseases. Based on previously reported antithrombotic effect for this plant, two new... L. has been traditionally used to treat various diseases. Based on previously reported antithrombotic effect for this plant, two new phenylpropanoid sucrose... |
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SubjectTerms | Acetic acid Acids Adenosine diphosphate anticoagulant Anticoagulants antiplatelet aggregation Aquatic plants Caffeic acid Canna indica Coagulation Esters Ethyl acetate Ferulic acid heart diseases Metabolites NMR Nuclear magnetic resonance phytochemicals Platelet aggregation Prothrombin Rhizomes Rosmarinic acid Secondary metabolites Sucrose Sucrose esters Thromboembolism Thrombosis |
Title | Potential antithrombotic effect of two new phenylpropanoid sucrose esters and other secondary metabolites of Canna indica L. rhizome |
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