Palmar fasciitis with polyarthritis syndrome in a patient with breast cancer

• Published in: Clinical rheumatology Vol. 30; no. 4; pp. 569 - 572
• Main Authors: Krishna, Kavya, Yacoub, Abdulraheem, Hutchins, Laura F, Kortebein, Patrick M
• Format: Journal Article
• Language: English
• Published: London London : Springer-Verlag 01.04.2011; Springer-Verlag; Springer Nature B.V
• Subjects: Adult; Anti-Inflammatory Agents - therapeutic use; Arthritis - diagnosis; Arthritis - drug therapy; Arthritis - etiology; breast neoplasms; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Carcinoma, Ductal - pathology; Carcinoma, Ductal - therapy; Case Based Review; Combined Modality Therapy; Fasciitis - diagnosis; Fasciitis - drug therapy; Fasciitis - etiology; Female; Humans; Mastectomy, Radical; Medicine; Medicine & Public Health; Naproxen - therapeutic use; Neoadjuvant Therapy; Palmar fasciitis and polyarthritis syndrome; Paraneoplastic syndrome; Paraneoplastic Syndromes - diagnosis; Paraneoplastic Syndromes - drug therapy; Paraneoplastic Syndromes - etiology; Prednisone - therapeutic use; Radiotherapy; Rheumatology; Palmar fasciitis and polyarthritis syndrome; Breast cancer; Paraneoplastic syndrome
• ISSN: 0770-3198; 1434-9949
• DOI: 10.1007/s10067-010-1592-2

Palmar fasciitis and polyarthritis syndrome (PFPAS) is a rare paraneoplastic syndrome often associated with ovarian and pancreatic cancers, and rarely lung and breast cancers. A 39-year-old patient with breast cancer underwent neoadjuvant chemotherapy, radical mastectomy, and radiation therapy. Subsequently, the patient developed PFPAS coinciding with progression of the breast cancer. The rheumatological symptoms were severe causing significant distress and handicap. The patient had a partial response to treatment with corticosteroids. A literature review of PFPAS and its relation to breast cancer is discussed.