Are coffee and tea consumption associated with urinary tract cancer risk? A systematic review and meta-analysis

• Published in: International journal of epidemiology Vol. 30; no. 2; pp. 353 - 362
• Main Authors: Zeegers, Maurice PA, Tan, Frans ES, Goldbohm, R Alexandra, van den Brandt, Piet A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.2001
• Subjects: Age Factors; bladder neoplasms; Case-Control Studies; Coffee; Coffee - adverse effects; epidemiology; Follow-Up Studies; Humans; meta-analysis; Odds Ratio; Risk; Sex Factors; Smoking - adverse effects; tea; Tea - adverse effects; urinary tract; Urologic Neoplasms - epidemiology; Urologic Neoplasms - etiology; urological neoplasms
• ISSN: 0300-5771; 1464-3685
• DOI: 10.1093/ije/30.2.353

Background Narrative reviews have concluded that there is a small association between coffee consumption and an increased risk of urinary tract cancer, possibly due to confounding by smoking. No association for tea consumption has been indicated. This systematic review attempts to summarize and quantify these associations both unadjusted and adjusted for age, smoking and sex. Method Thirty-four case-control and three follow-up studies were included in this systematic review. Summary odds ratios (OR) were calculated by meta-regression analyses. Results The unadjusted summary OR indicated a small increased risk of urinary tract cancer for current coffee consumers versus non-drinkers. The adjusted summary OR were: 1.26 (95% CI : 1.09–1.46) for studies with only men, 1.08 (95% CI : 0.79–1.46) for studies with only women and 1.18 (95% CI : 1.01–1.38) for studies with men and women combined. Neither unadjusted nor adjusted summary OR provided evidence for a positive association between tea consumption and urinary tract cancer. Even though studies differed in methodology, the results were rather consistent. We did not perform dose-response analyses for coffee and tea consumption due to sparse data. Conclusions In accordance with earlier reviews, we found that coffee consumption increases the risk of urinary tract cancer by approximately 20%. The consumption of tea seems not to be related to an increased risk of urinary tract cancer.