Anti-cancer effect of toosendanin and its underlying mechanisms

Toosendanin (TSN) is a triterpenoid purified from the medicinal herb Melia toosendan Sieb. et Zucc and has been used as an insecticide for decades. Recent studies have attracted increasing interest of TSN due to its novel anti-cancer effect in diverse cancer models. The broad spectrum anti-cancer ac...

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Bibliographic Details
Published inJournal of asian natural products research Vol. 21; no. 3; pp. 270 - 283
Main Authors Zhang, Sha, Cao, Liang, Wang, Zong-Ren, Li, Zhe, Ma, Jing
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 04.03.2019
Taylor & Francis Ltd
Subjects
Anticancer properties
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
apoptosis
autophagy
Cancer
Cell Cycle
Cell survival
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - pharmacology
estrogen receptor
Estrogen receptors
Estrogens
Glioblastoma
Herbal medicine
Insecticides
Medicinal plants
Molecular Structure
Neoplasms - drug therapy
p53 Protein
Toosendanin
Toosendanin
apoptosis
autophagy
cell cycle
estrogen receptor
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Summary:Toosendanin (TSN) is a triterpenoid purified from the medicinal herb Melia toosendan Sieb. et Zucc and has been used as an insecticide for decades. Recent studies have attracted increasing interest of TSN due to its novel anti-cancer effect in diverse cancer models. The broad spectrum anti-cancer activity suggests that TSN inhibits multiple pathways/targets that are critical for cancer cell survival and proliferation. Our recent study indicated that TSN has anti-cancer effect in glioblastoma through induction of estrogen receptor β (ERβ) and p53. This review highlights the anti-cancer efficacy of TSN and provides proof-of-principle insight into the underlying mechanisms.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2018.1451516