Fibrosarcoma complicating irradiated pituitary adenoma

Eight years after radiation therapy (5000 rads of 60Co) for a pituitary adenoma, a patient developed a sellar fibrosarcoma. The tumor had an aggressive growth pattern: it infiltrated the optic nerve, sphenoidal air sinus, hypothalamus, and both cavernous sinuses, where compression of the left intern...

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Bibliographic Details
Published inSurgical neurology Vol. 22; no. 3; pp. 277 - 283
Main Authors Shi, Tinghui, Farrell, M.A., Kaufmann, J.C.E.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.09.1984
Elsevier
Subjects
Adenoma, Chromophobe - radiotherapy
Biological and medical sciences
Cobalt Radioisotopes - adverse effects
Endocrinopathies
Fibrosarcoma
Fibrosarcoma - etiology
Fibrosarcoma - pathology
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Male
Malignant tumors
Medical sciences
Middle Aged
Neoplasms, Radiation-Induced - pathology
Pituitary adenoma
Pituitary Neoplasms - radiotherapy
Radiation
Radioisotope Teletherapy - adverse effects
Sella Turcica - pathology
Skull Neoplasms - etiology
Skull Neoplasms - pathology
Time Factors
Fibrosarcoma
Radiation
Pituitary adenoma
Endocrinopathy
Human
Pathology
Complication
Pituitary gland
Tumor
Adenoma
Malignant tumor
Radiotherapy
Antecedent
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Summary:Eight years after radiation therapy (5000 rads of 60Co) for a pituitary adenoma, a patient developed a sellar fibrosarcoma. The tumor had an aggressive growth pattern: it infiltrated the optic nerve, sphenoidal air sinus, hypothalamus, and both cavernous sinuses, where compression of the left internal carotid artery resulted in a massive hemispheric infarction. Surgery was ineffective in arresting rapid growth of the lesion; death occurring 5 months after onset of symptoms.
ISSN:0090-3019
1879-3339
DOI:10.1016/0090-3019(84)90014-4