Recent status of sesaminol and its glucosides: Synthesis, metabolism, and biological activities

• Published in: Critical reviews in food science and nutrition Vol. 63; no. 33; pp. 12043 - 12056
• Main Authors: Li, Qi-Zhang, Zuo, Zan-Wen, Liu, Yan
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 20.12.2023; Taylor & Francis Ltd
• Subjects: Antioxidants; biological activities; E-coniferyl alcohol; Food industry; Glucosides; Inflammation; Intestine; Isomers; Lignans; Lipids; Metabolism; Oilseed crops; Oilseeds; Seeds; sesaminol; sesaminol glucosides; structure; Synthesis; synthesis; biological activities; metabolism; sesaminol glucosides; structure; sesaminol
• ISSN: 1040-8398; 1549-7852
• DOI: 10.1080/10408398.2022.2098248

Sesamum indicum is a major and important oilseed crop that is believed to promote human health in many countries, especially in China. Sesame seeds contain two types of lignans: lipid-soluble lignans and water-soluble glucosylated lignans. The major glucosylated lignans are sesaminol glucosides (SGs). So far, four sesaminol isomers and four SGs are identified. During the naturally occurring process of SGs production, sesaminol is generated first from two molecules of E-coniferyl alcohol, and then the sugar is added to the sesaminol one by one, leading to production of SGs. Sesaminol can be prepared from SGs, from sesamolin, and through artificial synthesis. SGs are metabolized in the liver and intestine and are then transported to other tissues. They exhibit several biological activities, most of which are based on their antioxidant and anti-inflammatory activities. In this paper, we present an overview of the current status of research on sesaminol and SGs. We have also discussed their synthesis, preparation, metabolism, and biological activities. It has been suggested that sesaminol and SGs are important biological substances with strong antioxidant properties in vitro and in vivo and are widely used in the food industry, medicine, and cosmetic products. The recovery and utilization of SGs from sesame seed cake after oil processing will generate massive economic benefits.