Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl- L -Methionine

• Published in: Biomolecules & therapeutics Vol. 25; no. 4; pp. 434 - 440
• Main Authors: Kim, Ki Taek, Kim, Ji Su, Kim, Min-Hwan, Park, Ju-Hwan, Lee, Jae-Young, Lee, WooIn, Min, Kyung Kuk, Song, Min Gyu, Choi, Choon-Young, Kim, Won-Serk, Oh, Hee Kyung, Kim, Dae-Duk
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Applied Pharmacology 01.07.2017; 한국응용약물학회
• Subjects: Original; 약학; Enhancers; Vitamin U; S-methyl-L-methionine; Deposition; Skin permeation
• ISSN: 2005-4483; 1976-9148; 1976-9148; 2005-4483
• DOI: 10.4062/biomolther.2016.254

S-methyl- -methionine (SMM), also known as vitamin U, is commercially available as skin care cosmetic products for its wound healing and photoprotective effects. However, the low skin permeation expected of SMM due to its hydrophilic nature with a log P value of -3.3, has not been thoroughly addressed. The purpose of this study thus was to evaluate the effect of skin permeation enhancers on the skin permeation/deposition of SMM. Among the enhancers tested for the skin permeation and deposition of SMM, oleic acid showed the most significant enhancing effect. Moreover, the combination of oleic acid and ethanol further enhanced permeation and deposition of SMM through hairless mouse skin. Furthermore, the combination of oleic acid and ethanol significantly increased the deposition of SMM in the epidermis/dermis for 12 hr, which was high enough to exert a therapeutic effect. Therefore, based on the and studies, the combination of oleic acid and ethanol was shown to be effective in improving the topical skin delivery of SMM, which may be applied in the cosmetic production process for SMM.