Hydroxylation of (+)-menthol by Macrophomina phaseolina

Abstract Biotransformation of (+)-menthol with Macrophomina phaseolina led to hydroxylations at C-1, C-2, C-6, C-7, C-8 and C-9, with the C-8 position being preferentially oxidized. The resulting metabolites were identified as 8-hydroxymenthol (2), 6R-hydroxymenthol (3), 1R-hydroxymenthol (4), 9-hyd...

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Published inBiocatalysis and biotransformation Vol. 29; no. 2-3; pp. 77 - 82
Main Authors Musharraf, Syed Ghulam, Ahmed, Muhammad Arif, Ali, Rahat Azher, Choudhary, Muhammad Iqbal
Format Journal Article
LanguageEnglish
Published Informa Healthcare 01.03.2011
Taylor & Francis
Subjects
(+)-menthol
biotransformation
hydroxylation
Macrophomina phaseolina
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Summary:Abstract Biotransformation of (+)-menthol with Macrophomina phaseolina led to hydroxylations at C-1, C-2, C-6, C-7, C-8 and C-9, with the C-8 position being preferentially oxidized. The resulting metabolites were identified as 8-hydroxymenthol (2), 6R-hydroxymenthol (3), 1R-hydroxymenthol (4), 9-hydroxymenthol (5), 2R,8-dihydroxymenthol (6), 8S,9-dihydroxymenthol (7), 6R,8-dihydroxymenthol (8), 1R,8-dihydroxymenthol (9) and 7,8-dihydroxymenthol (10). Metabolites 6-10 are described here for the first time. Their structures were characterized by spectroscopic analysis.
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ISSN:1024-2422
1029-2446
DOI:10.3109/10242422.2011.577209