Hydroxylation of (+)-menthol by Macrophomina phaseolina
Abstract Biotransformation of (+)-menthol with Macrophomina phaseolina led to hydroxylations at C-1, C-2, C-6, C-7, C-8 and C-9, with the C-8 position being preferentially oxidized. The resulting metabolites were identified as 8-hydroxymenthol (2), 6R-hydroxymenthol (3), 1R-hydroxymenthol (4), 9-hyd...
Saved in:
Published in | Biocatalysis and biotransformation Vol. 29; no. 2-3; pp. 77 - 82 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Informa Healthcare
01.03.2011
Taylor & Francis |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Abstract
Biotransformation of (+)-menthol with Macrophomina phaseolina led to hydroxylations at C-1, C-2, C-6, C-7, C-8 and C-9, with the C-8 position being preferentially oxidized. The resulting metabolites were identified as 8-hydroxymenthol (2), 6R-hydroxymenthol (3), 1R-hydroxymenthol (4), 9-hydroxymenthol (5), 2R,8-dihydroxymenthol (6), 8S,9-dihydroxymenthol (7), 6R,8-dihydroxymenthol (8), 1R,8-dihydroxymenthol (9) and 7,8-dihydroxymenthol (10). Metabolites 6-10 are described here for the first time. Their structures were characterized by spectroscopic analysis. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1024-2422 1029-2446 |
DOI: | 10.3109/10242422.2011.577209 |